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I am sure that's an easy one for you and I hope I will get lots of good
suggestions from you. We are currently performing DNA analysis on parraffin
embedded node negative breast carcinomas and are in the process of
determining what constitutes a low SPF versus a high SPF. My questions are:
1. How many cases should you use for a lab specific determination? Are 50
cases enough?
2. Does one just determine the mean SPF for diploid cases and aneuploid
cases and then consider everything above the mean a high SPF and everything
below the mean a low SPF?
3. Or do you do "tertiles" and how are they interpreted?
4. Are there any recent "key references" for interpretation of ploidy of
breast ca's (besides the consensus review which is good but vague)?
5. How do your lab interpret ploidy analysis on breast ca's?
Thank you very much in advance for your help on this issue?
Dahl-Chase Diagnostic Services
Flow Cytometry
345 State Street
Bangor, Maine 04401
Tel: (207) 941-2355
Fax: (207) 990-4848
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