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We would like to relate the altered expression
density of surface glycoproteins on platelets in
a certain genetic defect to the actual surface
area of the giant platelets. Light scatter characteristics
of platelets are, however, widely heterogeneous
already in normal samples probably due
to the highly heterogeneous shape of platelets.
Is anyone aware of a specifc method for quantitatively
labeling the surface membranes of platelets. Alternatively,
did anyone try to change platelet shape to spheres, e. g. by
SDS treatment similar to the erythrocyte method in
Technicon instruments.
Gregor Rothe
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Institute for Clinical Chemistry and Laboratory Medicine
University of Regensburg
D-93042 Regensburg, Germany
Tel. +49 (941) 944-6204
Fax +49 (941) 944-6202
Internet: Gregor.Rothe@klinik.uni-regensburg.de
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