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To the best of my knowledge there are no single markers specific for any
particualr leukaemia, if only there were! Markers on or in leukaemic cells exist
on normal haemopoetic cells at some point of normal cell development. However
all is not lost, in a great number of leukaemias there is asynchronous or
atypical antigen expression of two or more markers which do not exist or occur
very rarely on normal bone marrow cells. Such unusual coexpressions can be used
to asses minimal residual disease and may provide therapeutic targets.
A couple of papers which may be useful:
C L Reading et al. Expression of unusual immunophenotype combinations in acute
myelogenous leukemia. Blood 81. 3083-3090. 1993
J Drach et al. Flow cytometric determination of atypical antigen expression in
acute leukaemia for the study of minimal residual disease. Cytometry 13.
893-901. 1992
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Len Brown 102554.2147@compuserve.com
Department of Haematology (968)515736 voice
Sultan Qaboos University (968)513419 fax
Al Khod, Code 123, Sultanate of Oman
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