Re: hematagones vs ALL?

Mrloken@aol.com
Thu, 28 Mar 1996 15:46:42 -0500

The antigen expression of normal B lymphoid cells is heterogeneous but with a
distinct relationship between antigens. The combination of antigens change
during normal development and can be used to define 4 stages which are quite
distinct(1,3). These relationships are maintained from fetal development to
the elderly and following chemotherapy and bone marrow transplantation(2).
The phenotypes of B-ALL do not fit into these stages and therfore can be
used to identify the leukemic cells based on their aberrancy of antigen
expression(4). Therefore, hematogones follow normal development while
residual ALL have abnormal phenotypes which can be distinguished down to 0.1%
post therapy(5).

1. Loken et al. Blood 70:528-531, 1988
2. LeBien et al. Leukemia 4: 354-358, 1990
3. Ryan et al. Blood 68:417-425, 1986
4. Hurwitz et al. Blood 72:299-307, 1988
5. Wells et al. Blood 86: 3132 (Supp1), 1995

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