Re: Clinical Question
Bruce Davis, MD - Clinical Pathology (bdavis@beaumont.edu)
Wed, 28 Feb 1996 14:41:05 -0500 (EST)
I would favor a best fit as LGL-T cell type. T cell receptor rearrngement
studies for clonality would be of interest, but does not change the fact
that Maryalice is correct in interpreting this a a malignant chronic
lymphoproliferative disorder.
Bruce H. Davis, M.D.
Wm Beaumont Hosp.
On Wed, 28 Feb 1996, STEVEN DAVID GORE wrote:
>
>
> On Mon, 26 Feb 1996, Maryalice Stetler-Stevenson wrote:
>
> >
> > Flow: 75% lymphocytes with 97% T-cells. Approximately 70% of the
> > lymphocytes are CD3+ T-cells with abnormally dim CD2, CD5 and CD7
> > expression; bright CD8; negative for CD56 and CD16 as well as + for CD38
> > and HLADR. They are alpha beta T-cells.
> > I think this is highly abnormal and I bet malignant. Any comments?
> >
>
> Why not T-CLL? I'd see if TCR-beta showed a clonal rearrangement.
>
>
> Steve GOre
> Johns Hopkins Oncology Center
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