I think these are thymocytes. Melanie O'Donahue, MT, ASCP Mayo Clinic Scottsdale Flow Cytometry 480-301-8028 Odonahue.Melanie@mayo.edu -----Original Message----- From: Calin Tatu [mailto:dns@mail.dnttm.ro] Sent: Monday, January 12, 2004 13:26 PM To: cyto-inbox Subject: CD4-CD8- T cells in pediatric AIDS Hi! We are consistently finding a double negative (i.e., CD4-CD8-) population of T cells in most of our cases of pediatric AIDS and we have some difficulty in explaining the origin and nature of this population. In certain cases these cells can make up to 7-8% of the total number of CD3 cells from the peripheral blood. They seem to be some large lymphocytes expressing high levels of cell surface CD3. We have invariably seen this population using CD4/CD8 antibodies from different sources, so a staining artifact would be unlikely. Any input would be appreciated! Thanks a lot for your help, Calin.Received on Thu Jan 15 15:18:00 2004
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