From: Tytherleigh, Lynette (Lynette.Tytherleigh@health.wa.gov.au)
Date: Tue Dec 16 2003 - 03:30:04 EST
I am interested in clinical comments about flow cytometry lymph node results from a 36 year old male with a mediastinal lymphadenopathy. The lymphoid cells from a mediastinal node were 80% CD3, 47% CD4, 87% CD5 and 29% CD8 positive with 61% co-expression of CD3 and CD79b and 71% co-expression of CD5 and CD79b. There was 15% CD19, 15% CD20, 9% Kappa and 4% Lambda with 4% co-expression of CD5 and CD19 and 14% CD19+/CD20+/CD79b+ cells. Has anyone else seen examples of co-expression of CD3, CD5 and CD79b? Unfortunately we had insufficient sample to send for T cell gene rearrangement studies. Could this possibly be a T cell malignancy with aberrant expression of CD79b? Looking forward to receiving comments on this case. Lynette Tytherleigh Flow Cytometry Unit Haematology Department Fremantle Hospital Alma St Fremantle 6959 Western Australia Phone: 08 94312459 Email: Lynette.Tytherleigh@health.wa.gov.au
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