From: Richard Haugland (richard.haugland@probes.com)
Date: Fri May 10 2002 - 18:31:22 EST
Eosin Y (Drug and Cosmetic [D&C] Red No. 21 or #22?) has been routinely
used in lipsticks and is fluorescent (Quantum yield ~0.08 at pH 7 with
spectra a bit longer wavelength than fluorescein). It may be a diuretic,
however.
The Food and Drug Administration (FDA) divides certified colors into the
following 3 groups: FD&C colors, D&C colors, and External Drug and
Cosmetic colors. Only the first 2 groups can be used in lipsticks. The
External Drug and Cosmetic colors can only be used in locations where
they are not likely to enter the mouth.
Only eosin manufactured and certified for this purpose should be used
since commercial eosin is often impure. I would not want the liability
of doing this in humans, incidentally. Also yields red urine.
Also see this caution: Gatto C, Hale CC, Xu W, and Milanick MA. Eosin, a
potent inhibitor of the plasma membrane Ca pump, does not inhibit the
cardiac Na-Ca exchanger. Biochemistry, 34:965-972, 1995.
Alan Bishop wrote:
> Sorry to contradict but Rhodamine B is not a food dye, at least if it
> ever was it certainly isn't any longer, neither the FDA or ANZFA list
> it as such and our chemical database here lists it as toxic.
>
>
>
HAZARDOUS ACCORDING TO WORKSAFE AUSTRALIA CRITERIA.
CONSIDERED A DANGEROUS SUBSTANCE ACCORDING TO DIRECTIVE
67/548/EEC, POINT 4;
AND HAZARDOUS ACCORDING TO OSHA 29 CFR 1910.1200 (USA).
>
CAS BP
RN: 81-88-9,69381-99-3 NIOSH: 3675000 HAZCHEM: None
UN NO: None DGNONE Pack None
Class: Group:
Sch
Pois: None EPG: NONE IERG: NONE
>
> CHEMWATCH HAZARD RATINGS
>
>
>
>
>
>
>
>
>
>
R R22 R41
Codes: R51
R40(3)
R46(2)
S S53 S40
Codes: S35
S13
> R Statements:
> • Harmful if swallowed.
> • Risk of serious damage to eyes.
> • Toxic to aquatic organisms.
> • Exposure may produce irreversible
> effects*.
> • May produce genetic damage*.
> * (limited evidence).
> S Statements:
> • Avoid exposure - obtain special
> instructions before use.
> • To clean the floor and all objects
> contaminated by this material, use water.
> • This material and its container must be
> disposed of in a safe way.
> • Keep away from food, drink and animal
> feeding stuffs.
> -----Original Message-----
> From: Michael Kuhn [mailto:mkuhn@helixresearch.com]
> Sent: Friday, 10 May 2002 00:30
> To: Cytometry Mailing List
> Subject: Re: fluorochromes in food
>
> Rhodamine B is used as a dye in foods and is fluorescent.
> Of the food dyes, Rhodamine B likely has the highest quantum
> yield in water and is relatively insensitive to pH changes
> near neutral (pH 4 to 10). Michael Kuhn, PresidentHelix
> ResearchFluorescence Chemistry
>
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