From: Maryalice Stetler-Stevenson (stetler@box-s.nih.gov)
Date: Fri Sep 11 1998 - 13:37:43 EST
Anna, Be careful when you say all. People will take you literally and exclude CLL if CD23 negative.Although almost all CLL is CD23 positive, we have seen CLL that is negative for CD23. Our analysis was late in the disease process and CD23 may have been lost- I don't know. Never say always or never in neoplasia. Maryalice >Hi, >CD23 is present on a subpopulation of normal B-cell - especially numerous >in tonsils and reactive lymph nodes. > All B-CLL are positive but not all B cell leukemias :-) >CD23 positivity is also found in many B-cell NHL. >Best wishes >Anna > > >At 17.23 1998-09-09 -0400, you wrote: >> >>There sure is a lot of discussion of HCL on this list lately. I usually >>couuldn't care for the clinical stuff but for those of you who might be >>interested... >> >>There was an HCL specific monoclonal made by David Posnett of Cornell >>Medical College called HC2 or 1H1 (I think) published in J. Exp Med in the >>late eighties. Maybe that is a more direct way of phenotyping hairy >>leukemias. And NO, CD23 is not on all B cells. B cell leukemias, yes. >>CD30 too.... What does this mean for their biology? No-one really knows. >> >> >> >> >Anna Porwit-MacDonald >Heamatopathology Lab. >Department of Pathology >Karolinska Hospital, Stockholm >anpo@mb.ks.se >tel.:+46-851775863 >fax.:+46-851775843 Maryalice Stetler-Stevenson Director Flow Cytometry Unit Laboratory of Pathology, NCI, NIH
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