From: Nebe, Thomas (thomas.nebe@ikc.ma.uni-heidelberg.de)
Date: Mon Sep 07 1998 - 11:14:53 EST
Dear Collegue, I suggest also to consider the differential diagnosis of HCL like splenic lymphoma with villous lymphocytes and the hairy cell variant that is resistant to interferon. The missing CD25 is strongly suggestive for the latter one. Clonality is often hard to prove by light chain restriction in HCL due to Fc receptor bound immunoglobulin. The monoclonal HC2 (no CD yet) helps to differentiate further the HCL-variant. A slide is also helpful to review morphology. The splenomegaly and thrombocytopenia are consistent and MDS diagnosis should be reviewed. There is a large experience at the Catovsky group at the Royal Marsden Hospital in London. I suggest to contact directly Dr. Estella Matutes (at RMH, Fulham Rd, London SW3 6JJ). Thomas Nebe Dr.med. C. Thomas Nebe Universitätsklinikum Mannheim Institut für Klinische Chemie und Molekulare Diagnostik Theodor-Kutzer-Ufer 1-3 D-68167 Mannheim Tel. +49 621 383-3485 FAX +49 621 383-3819 thomas.nebe@ikc.ma.uni-heidelberg.de PSE 75-1445
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