From: Anna Porwit-MacDonald (Anja.Porwit@mb.ks.se)
Date: Thu Sep 03 1998 - 10:10:43 EST
Hi, in both cases the immunophenotype can be consistent with marginal zone lymphoma (splenic? with or without villous lymphocytes?) For differentiation with HCL you could use CD103 (Bly7) and tartrate resistant acid phosphatase. Best wishes Anna At 17.52 1998-09-01 +0200, you wrote: > >I would like to submit two cases : > >case 1: 60-year-old male with splenomegaly without lymphoadenopathy, mild >lymphocytosis (WBC 9000, Ly 5000), Hb 10 gr/dl, PLTS 130.000 mm3. >Coombs positive with normal haptoglobin and bilirubine. Bone marrow with >focal lymphocytosis (40%). >Immunophenotype: CD19: 60%, CD5 neg, CD23 neg, CD25 neg, CD22 50%, CD11c >10%, k 50%, lambda 2%. > >case 2: 65-year-old female with splenomegaly without lymphoadenomegaly. >Cryoglobulimemia, HCV positive, lymphocytosis (ly 20.000). Bone marrow >infiltration (70%) by lymphocytes of little size. >Immunophenotype: CD19 67%, CD22 69%, CD23 neg, CD11c 20% (dim), CD25 neg, >lambda monoclonality. > > both cases have been previously caracterized by others as LLC, but I think >that the immunophenotypes are not consistent with either LLC or HCL. Is that >true or do anybody know variant forms of LLC or HCL with these phenotypes? > >Thank you in advance >Silvana > > > > > Anna Porwit-MacDonald Heamatopathology Lab. Department of Pathology Karolinska Hospital, Stockholm anpo@mb.ks.se tel.:+46-851775863 fax.:+46-851775843
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