From: silvana (S.Bonfigli@ipsoe.ss.cnr.it)
Date: Tue Sep 01 1998 - 10:52:07 EST
I would like to submit two cases :
case 1: 60-year-old male with splenomegaly without lymphoadenopathy, mild
lymphocytosis (WBC 9000, Ly 5000), Hb 10 gr/dl, PLTS 130.000 mm3.
Coombs positive with normal haptoglobin and bilirubine. Bone marrow with
focal lymphocytosis (40%).
Immunophenotype: CD19: 60%, CD5 neg, CD23 neg, CD25 neg, CD22 50%, CD11c
10%, k 50%, lambda 2%.
case 2: 65-year-old female with splenomegaly without lymphoadenomegaly.
Cryoglobulimemia, HCV positive, lymphocytosis (ly 20.000). Bone marrow
infiltration (70%) by lymphocytes of little size.
Immunophenotype: CD19 67%, CD22 69%, CD23 neg, CD11c 20% (dim), CD25 neg,
lambda monoclonality.
both cases have been previously caracterized by others as LLC, but I think
that the immunophenotypes are not consistent with either LLC or HCL. Is that
true or do anybody know variant forms of LLC or HCL with these phenotypes?
Thank you in advance
Silvana
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