From: Maryalice Stetler-Stevenson (stetler@box-s.nih.gov)
Date: Wed Jun 24 1998 - 07:04:37 EST
I would diagnose CD3 surface negativity in a CD4 restricted population in a
cervical lymph node as: consistent with T-cell neoplasm. Nice case.
Maryalice
>I just had a cervical node from a 88 yr old male with h/o lymphoma in 1982.
>As of yet I have been unable to determine what the phenotype was. In this
>biopsy the cells are medium sized; the B cells are polyclonal and
>unremarkable. The T cells have all pan T cell markers at about 75% -- except
>for CD3 which is expressed on only 24% of the cells. The CD3+ cells are a
>mix of CD 4 and CD8, but the CD3- T cells are only CD4.
>
>Any comments would be welcomed.
>Brent Dorsett
>Cancer Research Group
>Lenox Hill Hospital - NYC
Maryalice Stetler-Stevenson
Director Flow Cytometry Unit
Laboratory of Pathology, NCI, NIH
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