Re: PNH Question

From: Dr. Martin R. Hadam (Hadam.Martin@mh-hannover.de)
Date: Tue Apr 14 1998 - 05:18:57 EST


On Mon, 13 Apr 1998 10:42:37 -0500, Kenneth Ault wrote:

>We recently had a patient who appears to have PNH.  She  is lacking CD55
>and CD59 on her RBC, monocytes, and polys, but not on her lymphocytes. 
>Is this unusual?  I recognize that this is stem cell disorder that
>should involve all of the hematopoietic cell lines.  How often does it
>miss the lymphoid cells?

 Quite often. Expression on different cell lineages is highly variable
(and different for each of the PI-linked molecules)


Martin R. Hadam
Kinderklinik - Medizinische Hochschule
D-30623 Hannover
Germany
Email: Hadam.Martin@MH-Hannover.de


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