From: kcdol@samsung.co.kr
Date: Sun Mar 29 1998 - 17:22:04 EST
Dear list group members I would like to ask a question about cancer cell contamination during peripheral blood stem cell collection (PBSC). In order to check the efficacy and the yield of PBSC, we routinely test pre-, post-CBC, manual differential count, CD34 percentage and absolute count with ProCount kit (BDIS). Recently, we completed a four-PBSC procedure with COBE SPECTRA instrument on a 23 month-old neuroblastoma patient. After examination of stained slide smears of PBSC products, a few suspicious neuroblastoma cells were noted. We also compledted a seven-PBSC procedure with the same instrument on a non-Hodgkin's lymphoma patient and found atypical lymphoid-looking cells on stained slide smears of PBSC products. My concern is: Is there any institutions or laboratories out there which routinely perform tests to confirm unwanted cell contamination after PBSC? And if so, what's the protocol or strategies to do so? Any comments would be greatly appreciated. Thanks in advance. ------------------------------------------------------------ Chang-Seok Ki, MD 4th-year Residents, Dept. of Clinical Pathology Samsung Medical Center, Seoul, Korea E-mail. kcdol@samsung.co.kr ------------------------------------------------------------
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