From: mazharovm@juno.com
Date: Fri Mar 13 1998 - 07:00:48 EST
I am forwarding this message to flow cytometry mailing list. Mike Mazharov --------- Begin forwarded message ---------- From: NewTownLaw <NewTownLaw@aol.com> To: cyto-inbox Subject: Forwardeed message Date: Thu, 12 Mar 1998 22:12:26 EST Message-ID: <4c2c9757.3508a41d@aol.com> *********************************************************** An outside hospital recently referred us a bone marrow aspirate for a flow cytometry leukemia/lymphoproliferative evaluation from a 19 year old with anemia, fever and lymphocytosis. Although the outside pathologist did not see anything in either the marrow or peripheral blood except occasional variant lymphs, I was unable to persuade him to contact his hematologist to ask to cancel this study. Against my better judgement, we ran some basic markers and discovered that virtually all her granulocytes were CD33 negative. This result was replicated in 3 tubes. CD13 was normal, and only a small proportion of granulocytes were HLA-DR activated. I am aware of the neutrophil adhesion defects associated with absence of the CD11/CD18 complex, but I've never encountered absence of CD33 outside of leukemia or myelodysplastic syndromes, which this patient as far as I can determine does not have. Are there any inherited neutrophil disorders that lack CD33? Any suggestions for further investigations? Thanks Jeff Goldstein M.D. Wolfson Children's Hospital 800 Prudential Drive Jacksonville, FL 32207 (904) 202-8104 Fax (904) 202-8110 NewTownLaw@aol.com --------- End forwarded message ---------- _____________________________________________________________________ You don't need to buy Internet access to use free Internet e-mail. Get completely free e-mail from Juno at http://www.juno.com Or call Juno at (800) 654-JUNO [654-5866]
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