From: Steve Perfetto (sperfetto@hiv.hjf.org)
Date: Mon Mar 02 1998 - 19:11:03 EST
Marty, >From the most recent literature it would suggests that this process is non- reversible and tracks (at least in most cells) the DNA damage as measured by the TUNEL assay. And all of us in this field, I think, will agree that this is the ultimate terminal measurement. However, because Apoptosis is a kinetic event and because some cells progress more rapidly than others it would be a mistake to only rely upon one measurement of Apoptosis. Of course if you have the opportunity this process should be followed over time. SP Does the increase in Annexin V binding (epithelial cells) commit the cell to apoptosis? Marty Giedlin Pharmacology Chiron Corp
This archive was generated by hypermail 2.1.6 : Thu Jan 01 2004 - 17:35:14 EST
