From: Wood,Brent (wood@mail.labmed.washington.edu)
Date: Tue Dec 17 1996 - 05:15:25 EST
>Can anyone explain a CD3+CD8+ phenotype on CD20 positive gated cells in a >patient with a h/o lymphoma? We have seen a rare example of a T cell malignancy expressing CD20. In particular, one well documented case of mycosis fungoides demonstrated CD20 expression in addition to the typical CD3+, CD4+, CD7- immunophenotype on a marrow aspirate. This was confirmed by immunocytochemistry on the biopsy. Other rare cases have been reported in the literature. As expected, it is best not to rely on a single immunophenotypic marker to define the lineage of a neoplastic cell. Brent Wood MD PhD Univeristy of Washington Hematopathology Laboratory
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