From: Aki Hoji (akhst7+@pitt.edu)
Date: Wed Oct 23 1996 - 22:08:15 EST
>From Chris Reutelingsperger's and David Hedley's comment, it appears that surface exposure of PS takes place immediatedly after the commitment stage, a point of no return, of apoptosis. My initial concern was that PS expression might be reversible but after reading all the comments posted, it does not appear to be the case. Or, am I wrong ? Also, what is a biological significance of surface expression of PS. Does it signal phagocytes (i.e. macrophage) to eat apoptotic cells ? Fianlly, I have to agree with David Hedley's last comment. In fact, I see Annexin V staining, and Tdt assay as tools to detect (not even measure) apoptosis but apoptosis itself has a lot more interesting aspects to it. And it was quite surprised to know that platelets did show Annexin V binding when they undgergo apoptosis, as mentioned by Vincent Shankey. Aki Hoji (akhst7+@pitt.edu) Dept. Infectious Diseases and Microbiology University of Pittsburgh
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