re: Annexin V

From: C.Reutelingsperger@BIOCH.RULIMBURG.NL
Date: Wed May 01 1996 - 06:14:44 EST

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Hi Lucy,

Your question concerns a very interesting subject. We have measured Annexin V binding to a large 
number of cell types under a variety of apoptosis inducing conditions. We found that PS exposure occurs 
soon after the activation of the apoptotic program in the absence of visible morphological changes at the 
EM level. As yet we did not find conditions that reversed the process. So, until someone proves 
otherwise, surface exposure of PS indicates COMMITMENT to execute the whole apoptotic program.

Chris Reutelingsperger, Ph.D.
Department of Biochemistry
University of Limburg
Maastricht, the Netherlands 

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