Re[2]: Phenotype for CML cells

From: mann0002@mc.duke.edu
Date: Tue Dec 19 1995 - 09:24:27 EST

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Michael Weaver writes:

   The blast cells which appear during acute transformation of CML have
been charaterized as resembling lymphoblasts (ie. CD10+/CD19+).  

This is true in lymphoid blast crisis, but in myeloid blast crisis the blast 
cells of course have a myeloid phenotype.  Myeloid blast crisis occurs in about 
75% of cases and lymphoid in about 25% of cases. (I'm sure this was just an 
oversight in your post, but thought I would make this clear for those with less 
experience with hematologic disorders).

Karen Mann
Clinical Flow Cytometry
Duke University Medical Center
Durham, NC

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