From: Steven Gore (sdgore@welchlink.welch.jhu.edu)
Date: Tue Dec 19 1995 - 09:30:46 EST
Blast crisis in CML is myeloid in 60 - 80% of cases. In such cases, the phenotype is analogous to AML phenotypes. The "B-lineage" ALL equivalent makes up the majority of the rest, with a very rare T cell case here and there. In each instance, the blast phenotype is equivalent to the comparable acute leukemia phenotype. Blast crisis in CML is more likely to have expression of mixed lineage antigens, as well as true "biphenotypic" leukemia: that is, two blast populations, one myeloid and one lymphoid. The other thing is that a lymphoid blast crisis put into remission can relapse as a myeloid blast crisis and vice versa. Steve Gore Johns Hopkins Oncology Center
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