From: Michael Weaver (weaver@freenet.vancouver.bc.ca)
Date: Mon Dec 18 1995 - 14:09:53 EST
Dear Roger: The blast cells which appear during acute transformation of CML have been charaterized as resembling lymphoblasts (ie. CD10+/CD19+). At other times the bone marrow phenotype can be quite heterogeneous. In my experience you could expect to see a wide variety of myeloid precursors and the proportions of each would be variable over time. I usually advised our hematologists against monitoring CML patients since it was difficult to make sense of the dysplastic changes evolving. In an individual undergoing blast transformation in the setting of a long-standing myelodysplastic disorder I think the flow would be very useful since therapeutic decisions may depend on it. As to your questions about culturing cells, I can't offer any advice. Good luck. Michael Weaver 6731 Steveston HIghway Richmond, B.C., V7E 2L2
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