SIS Fact Sheet
SIS material is a refined, naturally-occurring extracellular matrix (ECM) derived from porcine small intestine.
Physical
SIS material has inherent biological variations but is remarkably uniform in appearance and structure.
It is white to off-white in color; translucent when wet and opaque when dry.
Wet SIS material is ~90% water. Dry SIS material is ~90% collagen.
SIS material is pliable, soft and slick when wet. It is paper-like when dry.
Chemical/Biochemical
SIS material is an acellular, collagen-based material.
A majority of the collagen is type I; type III and type V are also present.
It is known to also contain basic fibroblast growth factor (bFGF) and transforming growth factor beta (TGFß) in active and latent forms.
Other components found in SIS material include the glycosaminoglycans:
- hyaluronic acidFibronectin, a proteoglycan, and decorin, a glycoprotein are also present.
- chondroitin sulfates A and B
- heparin
- heparan sulfate
Mechanical
SIS material is differentially permeable with a water porosity more than 5x greater transmurally in one direction versus the other.
SIS material is anisotropic and is significantly stronger along its longitudinal axis.
SIS material exhibits some viscoelastic properties and behaves similarly to multifilament composites.