Dear experts in flow cytometry, I have two questions regarding markers of activation during persistent viral infection : 1. When performing functional assay in patients with chronic viral infection, do all tetramer+ cells secreting INF/TNF after peptide stimulation express activation markers like CD69/CD38 ? Which of these activation markers do you find more appropriate in this case? 2. Does effector, viral specific PBMC CD8+ express activation markers, or that would be only the case of CD8+ T lymphocytes that migrated directly in the site/tissue of inflammation. Thank you for sharing your experience. Have a nice day ! Michal Abel -- Michal Abel, MD, PhD Laboratory of Clinical Immunology INSERM U25 Necker Hospital, 161 Rue de Sèvres. Paris tel: 33 1 42 19 28 87 fax: 33 1 44 49 53 74
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