Re: newbie help with software compensation

From: David Novo (dave@denovosoftware.com)
Date: Fri Jun 14 2002 - 00:24:27 EST


Hi Marty,

Just to reassure you, FCS Express does use the linear model correctly. It may shock you
to learn that other people, aside from your friends at Treestar, can read Dr. Bagwell's
paper and actually understand it enough to implement the algorithms that he describes.

FCS Express allows you to enter the files with the single stained controls and it
calculates the matrix values based upon the data in the file. In addition, in order to
see how slight changes in the compensation can distort your data, you can change the
compensation values with sliders to see what happens. Its a great for teaching people
the difference between proper, over- and under- compensated data. You can also enter
a user defined value to smooth out the digitization errors that can occur in the low
end of lower resolution data.

If anyone finds any problems with the compensation (which hasn't happened yet), please
let me know and of course I will fix any errors. But until that happens, I think that
your assumption that FCS Express uses the linear model correctly is actually a very
good one.

-Dave

At 06:23 PM 6/12/02 -0700, you wrote:

>Lastly, of course, this assumes that Summit (and FCS-Express) do use
>the linear model correctly. In an older version of Summit I used,
>overcompensation resulted in data "bouncing" off the axis instead of
>being smashed down on the axis.



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