Sample differential, sample concentration, and the effect on abort rate

From: nregimbal@idecpharm.com
Date: Wed Apr 17 2002 - 14:59:12 EST


Howdy.

I am observing a behavior from my MoFlo that isn't making sense to me, so I
thought I'd pick some brains.  This is what I've got when I use a 100
micron tip, 30-ish PSI, ~43kHz, ~4k trig'd events/sec, sorting out DCs:


Concentrated sample, low sample differential, X events per second: High
abort rate 30-50%

Diluted sample, high sample differential to achieve the same (X) event
rate: Low abort rate ~10%


Purify 1-drop sort mode, and I'm using FSC pulse-width to 86 the
aggregates.  Aggregate percentages are the same whether I crank the diff.
or let it trickle, so it doesn't seem to me to be a coincidence thing.

Any thoughts, suggestions or strange looks are totally appreciated.

Regards from San Diego,

Nate

Nate Regimbal
IDEC Pharmaceuticals Corporation
Cell Biology Group
Ex. 8293



This archive was generated by hypermail 2b29 : Sun Jan 05 2003 - 19:26:07 EST