WHO Classification of Tumors

From: Bessie Kam (bkam@dls.queens.org)
Date: Fri Nov 16 2001 - 14:55:00 EST


Hello Flow community,

I have a few questions from looking over the above publication.

1.  How many are using CD65 in diagnosis of myeloid leukemias or for acute
leukemias of ambiguous lineage.  I noticed the scoring system from the
European Group for immunologic Classification of leukemia gives it a score
of 1.  I have not used it and wondered how prevalent and useful it is for
others.

2.  How common is the use of FMC7 for CLLs.  In the section on CLLs, there
is a scoring system of one point each which uses

SIg weak,
CD5 pos,
CD23 pos,
CD79b/CD22 weak and
FMC7 neg

looking for a score of 4-5 for CLL.  I am not using FMC7 but find CD43
helpful as well as intensity of stain and of course CD5 and CD23.  I also
use intensity of CD20 which I do not see listed.  What is your common
practice.  Also, how many are using CD79b.  I am not familiar with that
particular antibody.

thanks again,
bessie
--
Bessie Kam                                Email: bkam@dls.queens.org
The Queen's Medical Center, Pathology     FAX:   808-547-4045
                                          Phone: 808-547-4271



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