Dear Esper Georges Kallas, You referred to several publications from CLB and although Dörte Hamman is not within this research field any more she provided following comments to your e-mail: It is true that the distribution of CD4+ cells is different compared to CD8+ cells. Especially the cytotoxic effector cells CD8+ and CD45RA+CD27- are not present in the CD4+ cells. In stead you will find a higher percentage of CD45RA-CD27- cells which do also have effector function. Although using the superior CD27 FITC from CLB this did not change these findings. We assume that both CD45RA-CD27- as well as the CD45RA+CD27- cells are effector cells. Best regards, John John Voorn CLB Reagents Productmanager Plesmanlaan 125 j_voorn@clb.nl <mailto:j_voorn@clb.nl> 1066CX AMSTERDAM the Netherlands tel +31-(0)20 5123246 fax +31-(0)20 5123570 web site www.clb.nl <www.clb.nl>
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