special protocols for functional studies of frozen cells?

From: Maciej Simm (simmmmer@yahoo.com)
Date: Mon Oct 01 2001 - 15:48:00 EST


We're about to get a large batch of cells which have been
cryopreserved for several months.

One of the things I was asked to do is measure CD69 and inf-gamma
production by flow; are the cells ready to be activated after the
thawing procedure?

Or should I let them "recover" ? I know they have been
ficoll-isolated (which I have seen causing higher CD69 base level)
and I dont know what if any effect DSMO has on cells' activation
capabilities.

Aside from a viability check, are there any special treatments for
frozen cells in flow?

any feedback would be welcome,

maciej

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