Phil -- Many forms of radiation upregulate CD95 and, in at least some instances, the amount of CD95 upregulation tracks with the dose. So perhaps you could monitor CD95 expression as you use drug X to protect against radiation damage? -- Jim Leary James F. Leary, Ph.D. Chief, Molecular Cytometry Unit Division of Infectious Diseases 4.216 Mary Moody Northen Pavilion - Route 0435 Professor of Internal Medicine, Pathology, Microbiology & Immunology, Biophysics, Human Biological Chemistry & Genetics. and Biomedical Engineering University of Texas Medical Branch 301 University Blvd. Galveston, Texas 77555-0435 Tel: 409-747-0547; Fax: 409-747-0550 Email: jleary@utmb.edu -----Original Message----- From: Barren, Phil [mailto:BarrenP@MedImmune.com] Sent: Tuesday, September 25, 2001 2:58 PM To: cyto-inbox Subject: Any thoughts on the detection of Ionizing radiation effects in rats FLOWers I am in need of some help. We want to look at the protective effect of drug X on radiation induced damage in the rat, by Flow Cytometry. Does anyone have any thoughts?? I know this is potentially a very broad subject, but I would appreciate any thoughts on potential avenues of approach thank you for your time and help Philip Barren
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