Has anyone come up with a good means to quantitate bimodality? We are examining expression of a protein by basophils and certain donors demonstrate bimodal expression whereas most are clearly unimodal or very questionably bimodal. The distribution (unimodal or bimodal) has important implications for our conclusions. The only scheme I have come up with is to have several investigators score blinded samples (unimodal, questionably bimodal, clearly bimodal). A CV may yield more objective data but seems lacking. Any ideas would be appreciated. Calman
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