CD45- ALL is not so unusual particularly in precursor B. I have seen a few also. There is a case described in the Teaching CD ROM "Cases in Flow Cytometry" by Borowitz and Silberman. You may also want to check out these references. There are several more. Immunophenotype and clinical characteristics of CD45-negative and CD45-positive childhood acute lymphoblastic leukemia. Ratei R, Sperling C, Karawajew L, Schott G, Schrappe M, Harbott J, Riehm H, Ludwig WD. Ann Hematol. 1998 Sep;77(3):107-14. Lack of CD45 antigen on blast cells in childhood acute lymphoblastic leukemia is associated with chromosomal hyperdiploidy and other favorable prognostic features. Behm FG, Raimondi SC, Schell MJ, Look AT, Rivera GK, Pui CH. Blood. 1992 Feb 15;79(4):1011-6. CD45 expression and prognosis in acute lymphoblastic leukemia.Caldwell CW, Patterson WP, Hakami N. Blood. 1993 Jan 15;81(2):562-3. Comment on: Blood. 1992 Feb 15;79(4):1011-6 Hope this helps Judith Judith Chezar PhD Head Hematology and Blood Bank Laboratories Hospital of Western Galilee Nahariy Israel javicn@netvision.net.il
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