John Tell your pathologists to cheer up and dont waste anymore CD20; sIg- CD19+ tumors with variable to little expression of CD45 is not that unusual. F Preffer At 03:46 PM 6/27/2001 -0500, JOHN MARIO GONZALEZ _ PROFESOR DPT. MICROBIOLOGIA-. wrote: > >Hi colleges: > >We have a patient, a woman of 35 years old with 85,500 WBC/ul reported >as 97% blasts. Flow cytometry showed in SSC Vs CD45 most of the cells >with low complexity and all of them is an smear in CD45 between >negative, low and intermediate positive cells never reach the mature >CD45 high position. These population is rather similar in markers CD19+, >CD22+, CD20-, CD10-, CD34 -, sIg- and expressed CD5+ intermediate.They >are 90% of the BM. Patologist were not happy with CD20 and repeatly was >negative using adequate controls for the anti CD20 mAbs. T and myelod >markers are negatives.We are wating for the biopsy. > >Suggestions ? > >JOHN MARIO GONZALEZ M.D., Ph.D. Facultad de Ciencias Pontificia >Universidad Javeriana Phone 00 571 2850503 Fax 00 571 3208320 Ext 4085 > Frederic I. Preffer Department of Pathology Charlestown Navy Yard- 7140 149 13th Street Massachusetts General Hospital -East Charlestown, MA 02129 voice [617] 726-7481 fax [617] 724-3164
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