Fixation/Use uf PI

From: Kerstin Büttner (k.buettner@uke.uni-hamburg.de)
Date: Thu Mar 01 2001 - 11:17:31 EST


>I am just starting to use flow cytometry and am facing some problems:
>
>1. I am trying to measure intracellular antigen with FITC-labeled
Antibody, DNA content with PI and  viability of cells stained with EMA
prior to fixation at the same time. Has anybody experience with such an
approach? Will it work out?
>2. What kind of fixation ist best to use for measuring DNA-content and
intracellular antigens simultaneously?
>3. I am also trying to establish an assay with FITC and PE-labeled
Antibodies used parallel to PI-staining of dead cells. I found
controversial statements  concerning the parallel use of PE-labelling and
PI in literature. Has anyone advice?
>
>thanks very much ;-))
Kerstin Buettner
Institute of Biophysics and Radiobiology
University of Hamburg
Martinistr. 52
20246 Hamburg
Phone: 0049-40-42803-2938
Fax: 0049-40-42803-5139
E-Mail: k.buettner@uke.uni-hamburg.de



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