Hello, we have a difficult case that I would like to ask your opinion on: 3 months old boy admitted due to anal abscess, HB 86g/l, WBC 40x10e9/l, plt73x10e9/l. In blood and BM smears increase of lymphatic cells, some with nucleoli and basophil cytoplasm. In BM smears there is relatively normal erthro- and granulopoesis. Flow cytometry on blood showed 85% cells in lymphocyte/blast region. 86% of these were T cells positive for CD3, CD2, CD5, CD7 with CD4/CD8 ratio 1.0. There was a subpopulation of CD7+ cells with "dim" expression (56%) and all these were positive for HLA-DR. The CD4/CD8 ration in that population was also approx.1.0. Most T cells were negative both for CD45RA and CD45RO, but they were positive for CD45, CD28 and had dim expression of CD62L. There was no increase in CD56, CD57, CD25, CD69. TdT and CD34 was negative. B-cells were 12% and normal for age. The same results were fond in BM - with slightly lower proportion of T cells. Are these results characteristic for any known immunodeficiency? Other condition? Kind regards Anna Anna Porwit Hematopathology Lab. Department of Pathology, Radiumhemmet Karolinska Hospital, 171 76 Stockholm, Sweden Anja.Porwit@ks.se tel.:+46-851774518 fax.:+46-851775843
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