Re: dead cell descrimination with PI

From: Mark Kukuruga (kukuru@med.umich.edu)
Date: Thu Feb 08 2001 - 18:08:22 EST


Derek,
We do it often.
Is it necessary? . . . only if you feel that viability may effect your results.
Non-specific increases in antibody binding will often be seen on dead cells.  And,
using some sort of viability marker is certainly better than simply using light scatter.
MAK.

--
Mark A. KuKuruga, Managing Director
University of Michigan Flow Core
7416 CCGC 0946
(734) 647-3216, fax (734) 936-7376
kukuru@umich.edu


>>> Derek Schulze <flow@post.queensu.ca> 02/07/01 04:56PM >>>

As a general question, how many people out there are using PI to gate out
dead cells when immunophenotyping?  Is this really necessary?

Derek Schulze

Cancer Research Labs
Queen's University
353 Botterell Hall
Kingston, ON, K7L 3N6
(613) 533-6635

http://meds.queensu.ca/medicine/crl/



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