lymphocyte reaction to antigen in vitro

From: Heather Medbury (Heather_Medbury@wsahs.nsw.gov.au)
Date: Mon Nov 06 2000 - 00:31:37 EST


Hi all

Not strictly a flow question, but I plan on using flow to examine the cellular response

I wanted to look at the human immune response to particular antigens. Iwanted to add
antgien to  human leukocytes in culture and detect the immune response by flow and
proliferation assays.
I realise however that the immune response will involve a very small number of T cells
specific for the antigens, so I probably wouldnt be able to detect the response. Though
I would look by flow for the activated T cells and examine them only.

Any hints, comments or suggestions on whether it will work or how I can get it to work.
Any references you know of that may be useful

Thanks

Heather Medbury
Sydney Aus.



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