I will like to repost the question and concerns raised by Sharon F. Vogt, MT (ASCP) on 9/28/00. The following is copy of that message. I keep wondering about this . . . please help if you can. Where flow cytometry indicates a CD20 dimly positive population on a lymphoma (i.e., CLL) do you see a positive therapeutic effect? Apparently the answer is yes. What about when you have a CD20-negative lymphoma (i.e. diffuse large cell, B cell) that is positive by immunohistochemical staining with L26? It seems to me there is no _surface_ antigen for the mAb to bind, so that the value of Rituxan in this situation is questionable. Or is it that the mAb is internalized somehow and then can bind up the CD20 sites? Or a try-it-and-see approach? Please pass along any references I've missed or experiences you've had with this. Thanks! sharon Leonel W. Edwards, MD. Assistant Medical Director Department of Pathology and Laboratory Medicine Danbury Hospital -----Original Message----- From: Sharon Vogt [SMTP:svogt@bellsouth.net] <mailto:[SMTP:svogt@bellsouth.net]> Sent: Wednesday, November 01, 2000 10:40 PM To: Edwards, Leonel, M.D. Subject: Re: Rituxan for dim/negative CD20? > will it be possible for you to forward any responses to the question to me > or the list. I think it is very relevant to the clinically oriented members > of the list. I would if I had _received_ any responses. Feel free to re-post the question, mentioning that the original post received no replies. It is possible that studies are on-going, but no firm results are available. At this point, though, I think any opinions/unconfirmed findings are relevant. If you do get any info, please forward or reply to me directly (since I'm no longer on the list). I have unsubscribed from the list because I have accepted a new position that doesn't have the specificity of flow cytometry (though it is very dear to me). :( Thanks for checking back. (I hope we will get something out of this.) sharon -- Sharon F. Vogt, MT (ASCP) svogt@bellsouth.net <mailto:svogt@bellsouth.net> Dekalb Medical Center . . . soon to be: HCFA, regional office, ATL, GA
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