Hello, The phenotype you describe could be consistent with immunocytoma/marginal cell lymphoma. Morhologically the cells can have lymphoplasmocytoid aspect. If your patient has a WBC of 16 with 11% ly - what are other cells? Kind regards Anna At 10:44 2000-09-21 -0400, you wrote: > >A PB was sent to our lab for lymphoma/leukemia immunophenotyping. The >patient is a 70 year old man with a history of CLL. His total white count >was 16,000 with a lymphocyte count of 11%. Here is what we found on flow: >CD45 bright, CD20 bright ( 70% ), Lambda bright ( 60% ), Kappa 0%, CD19+, >CD22 Dim+ ( 65% ), CD23 Dim+ ( 55% ), FMC7 dim+, CD11c-, CD10-, CD43- ( on >B-cells ), CD5- ( on B-cells ). So in summary, the patient has no >coexpression of CD5 and CD19 as well as CD5 and CD20, has bright CD20 and >Lambda restriction, is CD23+ , CD10-. My question is: does this patient have >a variant of CLL, a CLL/PLL transformation, or a lymphocytoid leukemia? The >CD5 negativity and bright CD20 is not the standard pattern of CLL, and the >lack of FMC7 bright positivity doesn't go with PLL. Any insights from the >experts? Morphologically, the cells could be prolymphocytes but the >pathologist is not sure. > >Thanks! > >Francesca > > Anna Porwit Hematopathology Lab. Department of Pathology Karolinska Hospital, Stockholm Anja.Porwit@ks.se tel.:+46-851774518 fax.:+46-851775843
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