Hello, Does anybody have any experience with immunophenotyping of Transient myeloproliferative disorder in Down children? We have a patient, 14 days old with Down, enlarged liver, palpable spleen, HB normal, WBC 14 with some blasts, plt 90. In the bone marrow smears there are 23% blasts (rather large, no granula), granulopoiesis that is activated and differentiating well, normal erythropoiesis and quite a few lymphatic cells. Immunophenotyping showed a population in the blast region, positive for CD34, CD7, CD33, CD117, but not for Tdt, B and other T cell markers (incl. cyt CD3 and CD79a). A combination of CD34 and CD7 would suggest a pathological population as in incipient AML. However clinics may be consistent with TMD. All comments would be greatly appreciated! Anna Anna Porwit Hematopathology Lab. Department of Pathology Karolinska Hospital, Stockholm Anja.Porwit@ks.se tel.:+46-851774518 fax.:+46-851775843
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