We have detected CD79a in megakaryocytes, some leukemia myeloblasts, and
some T-lymphoblasts.
Dan Arber
____________________Reply Separator____________________
Subject: CD79a distribution
Author: aavery@CVMBS.COLOSTATE.EDU ("Anne Avery, DVM, PHD"
<aavery@CVMBS.COLOSTATE.EDU>)
Date: 09/12/2000 7:41 AM
Hello,
While this is not strictly a flow question, I suspect people on
this
list might have some experience with this issue. Many
veterinary
pathologists use anti-human CD79a to detect B lymphocytes,
usually in
cases of lymphoma. In the original report describing one clone
(HM47), reactivity with smooth muscle and pancreas was
described.
Has anyone else noted non-lymphoid tissues with reactivity to
this
antibody in any species including people? In particular we are
wondering about bone reactivity/osteosarcoma. Thank you.
Anne
====================================
Anne Avery, VMD, PHD
Department of Pathology
Colorado State Univ
Ft. Collins, CO 80523-1671, USA
voice:(970)491-1170
aavery@cvmbs.colostate.edu
====================================
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