Dear Sharon, My two cents worth: CD20 expression in mantle cell lymphoma is usually strong. Your case shows more characteristics of CLL/SLL with the weak CD22, weak surface immunoglobulin and weak CD20 staining. In our laboratory we would interprete your phenotype as CLL/SLL but would look at this, in conjunction with the morphology. Cyclin D1 testing, if you have access to it would be useful. We have had cases of CD23 negative CLL that did go on to exhibit the clinical course of CLL and not the more aggressive course of mantle cell lymphoma. Like you, they ended up being cases which generated interested discussion by the Clinicians. Regards, Michelle Michelle Petrasich Molecular Haematology Department of Molecular Medicine The University of Auckland Phone: (+64)(9) 373-7599 ext 6381 Fax: (+64)(9) 373-7492
This archive was generated by hypermail 2b29 : Sat Mar 10 2001 - 19:31:31 EST