Flow cytometry of RBCs

From: Bill Telford (telfordw@box-t.nih.gov)
Date: Tue Jun 27 2000 - 09:27:00 EST


Hello all...

A colleague sent me this query.  Any insight/advise?

Thanks!

Bill Telford

_____________________________
>Dear Bill,
>
>A colleague wanted to perform flow cytometry studies of the uptake of
>molecules in RBC's.   It would appear to me that it would be problematic
>with fluorescein/rhodamine due to the strong hemoglobin absorption in the
>RBC.  Do you have any idea about how long wavelength fluorophore [cy5 or
>Texas Red] is required for quantitative measures of RBC uptake (not ghosts
>but normal rbc's)?  Do you know of anyone who has done RBC uptake
>measuremetns with fluorescent labels by flow cytometry?
>
>Thanks,

>Bob



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