We have on rare occasions observed a significant population (~30% vs < 0.5% normal) of mouse periperal blood leukocytes that appear to co-express TcR-Beta and CD-45R (B-220). This is a transient event as the same mice sampled 3 days later do not show this population. The CD4 and CD8 percentages in these mice were normal. I have also heard anecdotal reports of a similar response following in vivo stimulation with Staph enterotoxin B. -Jim Weaver ************************************************* * * * James L. Weaver Ph.D. * * Division of Applied Pharmacology Research * * Office of Testing & Research * * CDER MOD-1, FDA * * 8301 Muirkirk Rd, Laurel MD 20708 * * * * Phone: 301-594-5879 * * Fax: 301-594-3037 * * Email:WEAVER@CDER.FDA.GOV * * * *************************************************
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