Olindo, Renno et al (below) describes induced B220 expression on mouse T-cells stimulated in vivo with SEB. Also, it is known that lpr and gld mice express CD4-/CD8- T-cells that are B220+. You might be counting B220 (CD45) on B-cells and T-cells (which you are already accounting for with CD4 and CD8 therfore counting some of the same cells twice). It is also expressed on other non-MHC restricted cells (NK, CTL, and LAK cells). Renno et al. Eur. J. Immunol. 1998.28:540-547. Matt Matthew Morrow, MS, MT (ASCP) Warren Magnuson Clinical Center National Institutes of Health Bethesda, MD mmorrow@nih.gov/mmorrow@mail.cc.nih.gov (301) 496-4879
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