Hi flowers, We have a 35 yo female patient whose disease was diagnosed as M3 (promeylocytic) leukaemia with a t(15;17) translocation in 1992. At that time her malignant population was CD34-CD33+CD13+HLADr- . In 1995 she relapsed, with a malignant population CD34+CD33+. In January this year she relapsed again with 50% CD45weak+CD34+CD33+CD13+myeloperoxidase+ cells that were CD15-CD11b-HLADr- in her bone marrow. After treatment with arsenic, she had a transient leucocytosis (up to 36x10^9/L) with 90% CD34-CD33+CD15+CD14+CD11b+ cells with a folded nucleus and a myelomonocytic appearance in her peripheral blood. This has now settled down to 5x10^6/L. We'd be interested to hear of any other experiences of arsenic-induced cells. Yours, beth Beth Rees Royal Hobart Hospital Hobart, Tasmania
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