bleed-over from doubling up?

From: Bunny Cotleur (bcotleur@ohio.net)
Date: Mon Jan 17 2000 - 07:49:29 EST


Fellow flowers-
I would like to get a consensus opinion on the following:
A Fellow I work with has been "doubling up" on stain (meaning mixing
lymphocyte markers, either CD4 or CD8 with monocyte/CD14 markers with
the SAME fluorochrome).  He feels that since you gate only on the Lymphs
or mono's, there is no cross-contamination or increase signal from the
wrong population.  Is this valid? Does anyone else do this?  Is one
fluorochrome (PE/FICT/PerCP) better than another? 
The primary reason we would like to is because we are using human cells
and barely have enough to run all the various analysis we'd like.   It
sounds a little too good....
-- 


Bunny Cotleur
Cleveland Clinic Foundation
Neurosciences NC30

216-444-1164





******************************************************************
When you do something, you should burn yourself completely, like a good
bonfire, leaving no trace of yourself.
(Shunryu Suzuki)



This archive was generated by hypermail 2b29 : Sat Mar 10 2001 - 19:31:03 EST