Innovative Reagents Quality Results
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Innovative Reagents Quality Results |
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| Platelets
are the smallest cellular component in the circulation. The primary role
of circulating platelets is to maintain hemostasis. The evaluation of platelets
by flow cytometry has proven beneficial in the investigation of many disease
states including inherited defects, cardiovascular disease including stroke,
and many other inflammatory processes. Flow cytometry can be used to evaluate
platelet surface glycoproteins, platelet activation status, and platelet
responsiveness to agonists. Appropriate sample handling, reagent preparation,
flow cytometric set-up, and data interpretation are critical for generating
reproducible results of platelet surface receptor expression and evaluating
platelet-derived microparticles, pro-coagulant platelets, and leukocyte-platelet
aggregates. Key elements of platelet sample preparation are described here.
For a more complete description of flow cytometric protocols used in the
evaluation of platelet function see Krueger LA et al. Immunophenotypic Analysis
of Platelets, Current Protocols in Cytometry (2002) 6.10.1 - 6.10.17.
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