>Hello Silvana, >Your description fits best the splenic immunocytoma or marginal zone B-cell lymphoma, they cannot be distinguished by phenotype only. You may want to check the reference below. > >Berger F, Felman P, Thieblemont C, Pradier T, Baseggio L, Bryon PA, Salles G, Callet-Bauchu E, Coiffier B. >Non-MALT marginal zone B-cell lymphomas: a description of clinical presentation and outcome in 124 patients. >Blood. 2000 Mar 15;95(6):1950-6 > >Kind regards >Anna > > >> >>I would like to submit a clinical case: >>54-year-old male with lymphocytosis ( WBC 50.000 mm3) , splenomegaly >>without lymphoadenopathy . Small lymphocytes in the PB, some of them with >>nucleoli, small amount of cytoplasm without villous , ipogammaglobulinemia >>with a small monoclonal component ( IgG K). At the Immunophenotype the >>lymphocytes are: CD19 ++, CD20 ++, CD22 ++, CD23 +, CD10 neg, CD5 neg, >>CD11c +, CD103 neg, FMC7 ++. >>Which lymphoproliferative disorder could match with this immunopheotype and >>such morphology? >>Thank you in advance for your help >>Silvana >> >> Anna Porwit Hematopathology Lab. Department of Pathology, Radiumhemmet Karolinska Hospital, 171 76 Stockholm, Sweden Anja.Porwit@ks.se tel.:+46-851774518 fax.:+46-851775843
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